Expression profiling of the -subunit isoforms of AMP-activated protein kinase suggests a major role for 3 in white skeletal muscle
نویسندگان
چکیده
Margit Mahlapuu, Carina Johansson, Kerstin Lindgren, Göran Hjälm, Brian R. Barnes, Anna Krook, Juleen R. Zierath, Leif Andersson, and Stefan Marklund Arexis AB, SE-413 46 Gothenburg; Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, and Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala Biomedical Center, SE-751 23 Uppsala; and Department of Surgical Sciences, Karolinska Institutet, SE-171 77 Stockholm, Sweden
منابع مشابه
The Effect of Eight Weeks Aerobic and Resistance Training on AMP-Activated Protein Kinase (AMPK) Gene Expression in Soleus Muscle and Insulin Resistance of STZ-Induced Diabetic Rat
Background: AMPK regulation is one of biggest target in T2D and metabolic syndrome research. Therefore, the present study is aimed to investigate The effect of 8 weeks aerobic and Resistance training on AMP-activated protein kinase (AMPK) gene expression in soleus muscle and insulin resistance of STZ-induced diabetic rat. Methods: The research method of present study was experimental. For this...
متن کاملLong-term regulation of AMP-activated protein kinase and acetyl-CoA carboxylase in skeletal muscle.
Evidence is accumulating for roles of AMP-activated protein kinase (AMPK) in controlling glucose uptake, fatty acid oxidation and gene expression in skeletal muscle. Relatively little is known, however, about the control of expression of the AMPK subunit isoforms. Marked differences are noted in subunit expression as a function of muscle fibre type. Expression of the gamma3 subunit isoform incr...
متن کاملEffects of thyroid state on AMP-activated protein kinase and acetyl-CoA carboxylase expression in muscle.
AMP-activated protein kinase (AMPK) consists of three subunits: alpha, beta, and gamma. Two isoforms exist for the alpha-subunit (alpha(1) and alpha(2)), two for the beta-subunit (beta(1) and beta(2)), and three for the gamma-subunit (gamma(1), gamma(2), and gamma(3)). Although the specific roles of the beta- and gamma-subunits are not well understood, the alpha-subunit isoforms contain the cat...
متن کاملCharacterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding.
The AMP-activated protein kinase (AMPK) cascade plays an important role in the regulation of energy homeostasis within the cell. AMPK is a heterotrimer composed of a catalytic subunit (alpha) and two regulatory subunits (beta and gamma). We have isolated and characterized two isoforms of the gamma subunit, termed gamma2 and gamma3. Both gamma2 (569 amino acids) and gamma3 (492 amino acids) have...
متن کاملAltered content of AMP-activated protein kinase isoforms in skeletal muscle from spinal cord injured subjects.
AMP-activated protein kinase (AMPK) is a pivotal regulator of energy homeostasis. Although downstream targets of AMPK are widely characterized, the physiological factors governing isoform expression of this protein kinase are largely unknown. Nerve/contractile activity has a major impact on the metabolic phenotype of skeletal muscle, therefore likely to influence AMPK isoform expression. Spinal...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2003